MolScript: A story of success and failure

A scientific paper I published in 1991 is on the list of ”The 100 most highly cited papers of all time”. The paper in question is

Per J. Kraulis
MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures.
J. Appl. Cryst. (1991) 24, 946-950

The Top 100 list is published in the 30 Oct 2014 issue of Nature magazine. The list contains the 100 most-cited papers in the entire scientific literature since 1900. The MolScript paper is number 82 on the list, with 13,496 citations.

Update! 26 Nov 2014: The MolScript paper is now Open Access! See the J. Appl. Cryst. web site or DOI:10.1107/S0021889891004399.

Here are a couple of images prepared using the MolScript program:

Ras p21, standard view
Ras p21, standard view

This image shows a schematic overview of the ras p21 protein, based on a 3D structure determined by Ernest Laue’s group, which I was a member of (Kraulis, PJ, et al, Biochemistry (1994) 12, 3515-3531). The ras p21 protein is a key component of growth signaling in the cell. In a large fraction of cancer cases, this molecule has been mutated, so that its normal regulatory function has broken down.

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